Anti-CD160 Polyclonal Antibody

英文名称Rabbit CD160 Polyclonal Antibody应用WB稀释比例WB1:500-1:2000交叉反应Human蛋白分子量20kDaGene ID11126保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human CD160性状Lyophilized or LiquidSwiss ProtO95971克隆类型Polyclonal Antibody来源Rabbit背景资料CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.