Anti-DROSHA Polyclonal Antibod

英文名称Rabbit DROSHA Polyclonal Antibody应用WB稀释比例WB1:500-1:2000交叉反应Human蛋白分子量159kDaGene ID29102保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原A synthetic peptide of human DROSHA性状Lyophilized or LiquidSwiss ProtQ9NRR4克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.