英文名称Mouse Lamin A Monoclonal Antibody别名Lamin A应用WB稀释比例WB1:1000 ICC交叉反应Human,Mouse,Rat蛋白分子量74kDaGene ID4000保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 69% Glycerol.亚型IgG2a免疫原Purified recombinant human LMNA protein fragments expressed in E.coli.性状Lyophilized or LiquidSwiss ProtP02545克隆号3D6-F4-B7克隆类型Monoclonal Antibody来源Mouse背景资料The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.