- $247 - 475
- Alomone
- 以色列
- AIP-006
- 2025年07月13日
- WB
- Rabbit
- 见官方网站
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
AIP-006
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
见官方网站
- 靶点：
见官方网站
- 抗体英文名：
Anti-Sigma-1 Receptor
- 抗体名：
Anti-Sigma-1 Receptor
- 规格：
25 µl, 50 µl, 0.2 ml
Anti-Sigma-1 Receptor
σ non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, Sigma1RCat #: AIP-006
Sizes: 25 µl, 50 µl, 0.2 ml
Source: Rabbit
Type: Polyclonal
Applications: WB
May also work in: IFC, IC, IP, IH
Reactivity: H, M, R
Application key:
CBE- Cell-based ELISA, FC- Flow cytometry, IC- Immunocytochemistry, IE- Indirect ELISA, IFC- Indirect flow cytometry, IH- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blotSpecies reactivity key:
H- Human, M- Mouse, R- RatCLICK HERE TO RECEIVE A 25 µl FREE TRIAL SAMPLE!
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human Sigma-1 Receptor. Anti-Sigma-1 Receptor antibody (#AIP-006) can be used in western blot analysis. It has been designed to recognize Sigma-1 Receptor from human, rat and mouse samples.
- Applications
- Specifications
- Scientific Background
- Related Products
Western blot analysis of rat liver (lanes 1 and 3) and mouse liver (lanes 2 and 4) membranes:
1, 2. Anti-Sigma-1 Receptor antibody (AIP-006), (1:200)
3, 4. Anti-Sigma-1 Receptor antibody preincubated with the control peptide antigen.
Immunogen
Peptide (C)SRGHSGRYWAEISD, corresponding to amino acid residues 113-126 of human Sigma-1 Receptor (Accession Q99720). Intracellular, C-terminus.
HomologyRat, mouse – identical.
PurityAffinity purified on immobilized antigen.
FormulationLyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Standard quality control of each lotWestern blot analysis.
Peptide confirmationConfirmed by amino acid analysis and mass spectrometry.
Storage before reconstitutionThe antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Reconstitution25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody concentration after reconstitution0.85 mg/ml.
Storage after reconstitutionThe reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Control antigen storage before reconstitutionLyophilized powder can be stored intact at room temperature for 2 weeks. For longer periods, it should be stored at -20°C.
Control antigen reconstitution100 µl double distilled water (DDW).
Control antigen storage after reconstitution-20ºC.
Preadsorption Control1 µg peptide per 1 µg antibody.
Scientific background
Sigma receptors were first identified as a subtype of opioid receptors. The different members of the family are differentially distributed in various parts of the CNS and are responsible for a vast range of functions and behaviors1. Today, sigma receptors are mostly considered to be a separate receptor family with two main subtypes characterized.
The sigma-1 receptor is encoded by a gene baring the same name and is a protein of 223 amino acids with two transmembrane domains and a typical endoplasmic reticulum localized signal near its short N terminus. Sigma receptors are mostly detected in the central nervous system with a high density in spinal cord, pons, medulla oblongata, red nucleus, cerebellum and hippocampus.
Sigma-1 is mainly localized on the mitochondrial associated endoplasmic reticulum membrane (MAM), forming a Bip chaperone structure with high sensitivity to the calcium ion. When activated by agonists such as cocaine or analgesics, sigma-1 receptors separate from BiP and translocate from MAM to other parts of the cell. Through regulation of inositol triphosphate (IP3) receptors, NMDA receptors, Dopamine receptors and voltage-gated Ca2+ channels, sigma-1 receptors can influence TCA cycle, oxidative stress, mitochondrial function, neuron plasticity and the release of various neurotransmitters.
The exact etiology and pathophysiology of Alzheimer’s disease is not fully understood. A few hypotheses suggest the involvement of Sigma-1 in the progression of Alzheimer’s disease. The suggested mechanisms include protection from Aβ toxicity, prevention of Tau protein hyperphosphorylation and the upregulation of acetylcholine release2.
References
- Mansour, A. et al. (1995) Trends. Neurosci. 18, 22.
- Jin, J.L. et al. (2015) Int. J. Clin. Exp. Med. 8, 4808.
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