手机验证
见官方网站
见官方网站
液体或冻干粉
-20°C
多克隆
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见官方网站
6个月
Rabbit
AIP-006
高
大量
上海信裕生物科技有限公司
Rabbit
WB
见官方网站
见官方网站
Anti-Sigma-1 Receptor
Anti-Sigma-1 Receptor
25 µl, 50 µl, 0.2 ml
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human Sigma-1 Receptor. Anti-Sigma-1 Receptor antibody (#AIP-006) can be used in western blot analysis. It has been designed to recognize Sigma-1 Receptor from human, rat and mouse samples.
Sigma receptors were first identified as a subtype of opioid receptors. The different members of the family are differentially distributed in various parts of the CNS and are responsible for a vast range of functions and behaviors1. Today, sigma receptors are mostly considered to be a separate receptor family with two main subtypes characterized.
The sigma-1 receptor is encoded by a gene baring the same name and is a protein of 223 amino acids with two transmembrane domains and a typical endoplasmic reticulum localized signal near its short N terminus. Sigma receptors are mostly detected in the central nervous system with a high density in spinal cord, pons, medulla oblongata, red nucleus, cerebellum and hippocampus.
Sigma-1 is mainly localized on the mitochondrial associated endoplasmic reticulum membrane (MAM), forming a Bip chaperone structure with high sensitivity to the calcium ion. When activated by agonists such as cocaine or analgesics, sigma-1 receptors separate from BiP and translocate from MAM to other parts of the cell. Through regulation of inositol triphosphate (IP3) receptors, NMDA receptors, Dopamine receptors and voltage-gated Ca2+ channels, sigma-1 receptors can influence TCA cycle, oxidative stress, mitochondrial function, neuron plasticity and the release of various neurotransmitters.
The exact etiology and pathophysiology of Alzheimer’s disease is not fully understood. A few hypotheses suggest the involvement of Sigma-1 in the progression of Alzheimer’s disease. The suggested mechanisms include protection from Aβ toxicity, prevention of Tau protein hyperphosphorylation and the upregulation of acetylcholine release2.
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