JN1957型重组人小泛素相关修饰物1(SUMO1)价格

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括JN1957型重组人小泛素相关修饰物1(SUMO1)价格在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：JN1957型重组人小泛素相关修饰物1(SUMO1)价格
品牌：百奥莱博
产地：国产|进口
英文名：Recombinant Human Small Ubiquitin-Related Modifier 1
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Val101在N端含有His标签。

SUMO1质量控制：＞95%(还原性SDS-PAGE)

SUMO1制剂：冻干品

SUMO1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

SUMO1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于SUMO1：
Small Ubiquitin-Related Modifier 1 (SUMO1) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 is not active until the last four amino acids of the carboxy-terminus are cleaved off. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins and may also regulate a network of genes involved in palate development.

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·重组人TNFα(TNFSF2)
编号：JN0438
英文名称：Recombinant Human Tumor Necrosis Factor alpha
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成。

TNFa/TNFSF2 (high active)质量控制：＞95%(还原性SDS-PAGE)


TNFa/TNFSF2 (high active)制剂：冻干品

TNFa/TNFSF2 (high active)保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TNFa/TNFSF2 (high active)复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TNFa/TNFSF2 (high active)：
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α. Synthesis of TNF-α can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice comp*(代"a")red with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.



JN1957型重组人小泛素相关修饰物1(SUMO1)价格关键词：重组人小泛素相关修饰物1,JN1957,重组人SUMO1,重组人小泛素相关修饰物1蛋白,重组小泛素相关修饰物1

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JN1957型重组人小泛素相关修饰物1(SUMO1)价格关键词：重组人小泛素相关修饰物1,JN1957,重组人SUMO1,重组人小泛素相关修饰物1蛋白,重组小泛素相关修饰物1

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