重组人Fc gamma RIIIA(CD16a)(FCGR3

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名称：重组人Fc gamma RIIIA(CD16a)(FCGR3A)
产地：国产|进口
编号：JN1829
英文名：Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gly17-Gln208在C端含有His标签。

Fc gamma RIIIA/CD16a/FCGR3A质量控制：＞95%(还原性SDS-PAGE)

Fc gamma RIIIA/CD16a/FCGR3A制剂：冻干品

Fc gamma RIIIA/CD16a/FCGR3A保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Fc gamma RIIIA/CD16a/FCGR3A复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Fc gamma RIIIA/CD16a/FCGR3A：
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.

关键词：重组人Fc gamma RIIIA,重组人CD16a,重组人Fc gamma RIIIA蛋白,JN1829,重组人FCGR3A


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