β-Nicotinamide mononucleotide烟

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β-Nicotinamide mononucleotide

CAS No. : 1094-61-7

MCE 国际站：β-Nicotinamide mononucleotide

产品活性：β-nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物，NAD⁺ 的关键中间体。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、阿尔茨海默病和肥胖相关并发症中的作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：酮、醛、酸

In Vitro: β-nicotinamide mononucleotide has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD⁺ biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.
The intracellular NAD⁺ levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD⁺ levels are dramatically increased by supplement of NAD⁺ precursors NAM or NMN (0.5-1 mM). NAD⁺ precursor NMN treatment inhibited CD8⁺ T cells activation and function.

In Vivo: β-Nicotinamide mononucleotide (500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction.
Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite β-Nicotinamide mononucleotide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD⁺ level of respective Nampt KO and β-Nicotinamide mononucleotide-treated tumors are confirmed.
β-nicotinamide mononucleotide ameliorates glucose intolerance by restoring NAD⁺ levels in HFD-induced T2D mice. β-nicotinamide mononucleotide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

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