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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江蓝纯
- 规格:
25mg
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| P9059-25mg | Mechano Growth Factor (机械生长因子) | 25mg | 1258.00元 |
| About this protein | |
| Product name | Mechano Growth Factor (机械生长因子) |
| Alternative names | MGF;IGF-1 Ec |
| Description | A local growth factor or a local tissue repair factor. Combining physiological and molecular biology methods have indicated how a factor expressed by stressed muscle induces local muscle fiber repair and adaptation. Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I), but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibers that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms. |
| Purity | >95%(HPLC) |
| CAS Number | N/A |
| Molecular Formula | C121H199N41O40 |
| Molecular Weight | 2868.19 |
| Sequence (Three-Letter Code) |
H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-OH |
| Source | Synthetic |
| Reconstitution | Dissolve in distilled water or DMSO |
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文献和实验指在组织培养中,除了氨基酸、维生素、葡萄糖以及无机盐等正常成分之外,其可以代替培养基血清高分子物质的而促进细胞生长的物质。与发育因子和增殖因子为同义词,但因在组织培养中是以细胞增殖为直接目的,所以称增殖因素较确切。生长因子多为广义的肽激素,有胰岛素、表皮生长因素(EGF)、成纤细胞生长因素(fibroblast gfowth factor,FGF)、血小板来源增殖因素(platelet-derivedgrowth factor,PDGF)以及生长
一类通过与特异的、高亲和的细胞膜受体结合,调节细胞生长与其他细胞功能等多效应的多肽类物质。存在于血小板和各种成体与胚胎组织及大多数培养细胞中,对不同种类细胞具有一定的专一性。通常培养细胞的生长需要多种生长因子顺序的协调作用,肿瘤细胞具有不依赖生长因子的自主性生长的特点。在分泌特点上,生长因子主要属于自分泌( autocrine)和旁分泌( paracrine)。许多生长因子已被提纯和确定了其结构组成。如血小板来源的生长因子( PDGF)是个热稳定、具较高正电荷的蛋白
表皮生长因子 epidermal growth factor
促进哺乳类和鸡表皮的增长、角蛋白化以及人的成纤细胞增殖的多肽性因子。是 S. Cohen( 1962年)最先从雄性小鼠的颌下腺取得的,具有促进初生小鼠眼睑睁开和门齿露出的作用。是由 53个氨基酸残基组成,分子量为 6045,可与组织内其他蛋白质结合,形成分子量约为 74000的大分子。除促进蛋白质和 RNA等的合成外,也具有对鸟氨酸脱羧酶的衍生作用。从小鼠颌下腺取得的神经生长因子是与此不同的物质。最近从人尿中也获得了与表皮生长因子相同的物质,已知它与胃液分泌抑制因子的尿抑
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