Active Interleukin 1 Receptor

Biosensor Analysis of Receptor-Ligand Interactions

domains of the multiple receptor subunits, phage-displayed forms of cytokine and receptor (often obtained for combinatorial epitope mapping and antagonist design studies), and membrane-incorporated forms of receptors such as in vesicles or pseudoviral

Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target: The Interleukin-1 Story

reduction in ischemic cell death seen when IL-1 receptor antagonist (IL-1ra) is administered. Mechanisms of IL-1 action remain largely unknown, but they may involve complex effects on many cells including microglia, astrocytes, neurons, and endothelial cells

Identification of Adipokine Receptor Agonists and Turning Them to Antagonists

organ that secretes a number of biologically active adipokines, including leptin and adiponectin. A recent discovery and design process for leptin and adiponectin receptor response modifier peptides can be generalized to a series