重组人4-1BBL(TNFSF9)价格

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博主要从事生物试剂的生产和销*(代"售")，产品线涵盖重组人4-1BBL(TNFSF9)价格在内的分子生物学试剂产品，还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。

名称：重组人4-1BBL(TNFSF9)价格
英文名：Recombinant Human 4-1BB ligand
品牌：百奥莱博
规格：10μg|50μg|500μg|1mg
产地：国产|进口
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Arg71-Glu254在C端含有His标签。

4-1BBL/TNFSF9质量控制：＞95%(还原性SDS-PAGE)

4-1BBL/TNFSF9制剂：冻干品

4-1BBL/TNFSF9保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

4-1BBL/TNFSF9复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于4-1BBL/TNFSF9：
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.

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·重组人小泛素相关修饰物3(SUMO3)
编号：JN0913
英文名称：Recombinant Human Small Ubiquitin-Related Modifier 3/SUMO3
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备而成(人类细胞)，目的蛋白包含序列(Met1-Phe103)。

SUMO3质量控制：＞95%(还原性SDS-PAGE)


SUMO3制剂：冻干品

SUMO3保存：
冻干蛋白长期保存应置于-20℃以下，常温可稳定保存3周。
复溶蛋白溶液可在4℃保存2～7天。
复溶后的蛋白溶液应尽量避免反复冻融，可根据使用量分装冻存在-20℃以下长达3个月。

SUMO3复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
Dissolve the lyophilized protein in 1X PBS.
复溶后，请根据用量分装冻存，避免反复冻融。

关于SUMO3：
Small Ubiquitin-Related Modifier 3 (SUMO3) is a member of the ubiquitin family. SUMO3 is a cytoplasmic protein and is expressed predominantly in the liver. It contains one ubiquitin-like domain. Unlike ubiquitin that targets proteins for degradation, SUMO3 participates in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. In addition, SUMO3 regulates amyloid beta generation and is pivotal in the onset or progression of Alzheimer’s disease.


重组人4-1BBL(TNFSF9)价格关键词：重组4-1BBL,重组人TNFSF9,JN0470,重组人4-1BBL蛋白


·重组人CDKN1B(细胞周期蛋白依赖性激酶抑制剂1B)
编号：JN0694
英文名称：Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Thr198在N端含有His标签。

CDKN1B质量控制：＞95%(还原性SDS-PAGE)

CDKN1B制剂：冻干品

CDKN1B保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

CDKN1B复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于CDKN1B：
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.


重组人4-1BBL(TNFSF9)价格关键词：重组4-1BBL,重组人TNFSF9,JN0470,重组人4-1BBL蛋白


·重组小鼠IL-27
编号：JN1645
英文名称：Recombinant Mouse Interleukin-27 subunit alpha and Interleukin-27 subunit beta
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Tyr19-Pro228&Phe29-Ser234在C端含有His标签。

IL-27质量控制：＞95%(还原性SDS-PAGE)

IL-27制剂：冻干品

IL-27保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-27复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-27：
IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. It is expressed on monocytes, endothelial cells and dendritic cells. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. IL-27 has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. IL-27 has also an effect on cytokine production. It suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.

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