Recombinant Human CD38 (CU65)
产品说明(Description)
Recombinant Human ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 1 is produced by our Mammalian expression system and the target gene encoding Val43-Ile300 is expressed with a 6His tag at the N-terminus.
Accession #: P28907
Known as: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1
制剂(Formulation)
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
质量控制(Quality Control)
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Bioactivity-Elisa: |
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Bioactivity-BLI: |
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Immobilized Anti-Human CD38 mAb(Cat#NC051) at 5μg/ml (100 μl/well) can bind Human CD38-His(Cat#CU65). The ED50 of Human CD38-His(Cat#CU65) is 62.2 ng/ml. |
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Loaded Human CD38-His(Cat#CU65) on HIS1K Biosensor, can bind Anti-Human CD38 mAb-Fc(Cat#NC051) with an affinity constant of <10-3 nM as determined in BLI assay. |
运输(Shipping)
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存(Storage)
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景(Background)
CD38, also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, is a Signal-anchor for type II membrane protein. CD38 is able to transform NAD+ to ADP-D-ribose and nicotinamide. It also can transform NADP+ to nicotinate-adenine dinucleotide phosphate and nicotinamide. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY