Recombinant Human Fumarase/FH

Recombinant Human Fumarase/FH  (C224)

 

产品说明(Description)

Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed. 

Accession #: P07954

Known as: Fumarate Hydratase Mitochondrial; Fumarase; FH

 

制剂（Formulation）

Supplied as a 0.2 μm filtered solution of 20mM Tris, pH 8.0.

 

质量控制（Quality Control） 

 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

 

运输（Shipping）

The product is shipped on dry ice/polar packs. 

Upon receipt, store it immediately at the temperature listed below.   

 

保存（Storage）

Store at ≤-70°C, stable for 6 months after receipt. 

Store at ≤-70°C, stable for 3 months under sterile conditions after opening. 

Please minimize freeze-thaw cycles.

 

背景（Background）

Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.

 

电泳(SDS-PAGE)

 

FOR RESEARCH USE ONLY