Recombinant Human ALDOA/Fructose-bisphosphate aldolase A (C202)
产品说明(Description)
Recombinant Human Fructose-Bisphosphate Aldolase A is produced by our E.coli expression system and the target gene encoding Pro2-Tyr364 is expressed with a 6His tag at the C-terminus.
Accession #: P04075
Known as: Fructose-Bisphosphate Aldolase A; Lung Cancer Antigen NY-LU-1; Muscle-Type Aldolase; ALDOA; ALDA
制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, pH 8.0.
质量控制(Quality Control)
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
运输(Shipping)
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存(Storage)
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景(Background)
Fructose Bisphosphate Aldolase A (ALDOA) belongs to the class I fructose-bisphosphate aldolase family. ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, Aldolase A in muscle, Aldolase B in liver and aldolase C in brain. Aldolase A Interacts with SNX9 and WAS. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. In addition, Aldolase A plays an important role in glycolysis and gluconeogenesis; it may also act as a scaffolding protein.
电泳(SDS-PAGE)
参考文献(Reference)
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate[J]. Wei Qin. et al. Nature Chemical Biology. 2019.
Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy[J]. Francesca D’Addio. et al. Cell Stem Cell. 2015.
INHIBITORS OF IGFBP3 BINDING TO TMEM219 FOR TREATMENT OF INTESTINAL DISEASES[J]. D'addio Francesca. et al. 2020.
FOR RESEARCH USE ONLY