Recombinant Human FKBP3 (N-6His) (CH60)
产品说明(Description)
Recombinant Human 25 kDa FK506-binding protein is produced by our E.coli expression system and the target gene encoding Met1-Asp224 is expressed with a 6His tag at the N-terminus.
Accession #: Q00688
Known as: Peptidyl-prolyl cis-trans isomerase FKBP3;PPIase FKBP3;25 kDa FK506-binding protein;25 kDa FKBP;FKBP-25;FK506-binding protein 3;FKBP-3;Immunophilin FKBP25;Rapamycin-selective 25 kDa immunophilin;Rotamase;FKBP25
制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0.
质量控制(Quality Control)
Purity: |
Greater than 95% as determined by reducing SDS-PAGE. |
Endotoxin: |
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
运输(Shipping)
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存(Storage)
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景(Background)
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY