- ￥1200 - 3520
- 近岸蛋白(Novoprotein)
- CK34
- 中国
- 2025年11月13日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human IL-15 R alpha/IL-15Rα
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3520.0 |
| 规格： | 500ug | 产品价格： | 询价 |
| 规格： | 1mg | 产品价格： | 询价 |
Recombinant Human IL-15 R alpha/IL-15Rα (CK34)
产品说明(Description)
Recombinant Human Interleukin-15 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Ile31-Thr172 is expressed with a Fc tag at the C-terminus.
Accession #: Q13261-3
Known as: CD215; IL15RA; CD215 antigen; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin 15 receptor; alpha; interleukin-15 receptor subunit alpha; MGC104179
制剂（Formulation）
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
质量控制（Quality Control）
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Bioactivity: Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells.
The ED50 for this effect is 0.35-3.5 ng/ml.
复溶（Reconstitution）
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
保存（Storage）
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
背景（Background）
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY
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文献和实验7, and IL-9 receptors, and a unique a-chain. The α-chain of the IL-15 receptor (IL-15Rα) and IL-2Rα share a fragmentary sequence homology and structural similarities, and both proteins contain a conserved “sushi domain” binding motif. IL-15 is a potent T
() #交换 x 轴和 y 轴> p + ylim(0,15) #如果想截取某一段可以用此命令设置值域。> p + scale_x_continuous(breaks =seq(18,34,50) ) #设置刻度线位置> p + theme(axis.text.x = element_text(angle = 90,family = "Times",face = "italic",colour = "darkred",size=rel(0.9))) # angle = 90 设置字体角度, family
有氧运动真的能抗癌！Cancer Cell：一周 5 次、每次 30 分钟，就可助力免疫系统杀死癌细胞
发表题为 Exercise-induced engagement of the IL-15/IL15-Rα axis promotes anti-tumor immunity in pancreatic cancer 的文章，研究发现本是针对细菌性侵入的哺乳动物免疫系统竟可以识别癌症细胞，而运动诱导的肾上腺素分泌上升调节对白介素 15（IL-15）有响应的免疫细胞，从而延缓胰腺癌在小鼠上的增殖。IL-15 超级激动剂 NIZ985 可模拟运动产生的有益效果，使「癌王」对免疫治疗敏感。 图片来源
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