EIPA,1154-25-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

EIPA

CAS No. : 1154-25-2

MCE 国际站：EIPA

产品活性：EIPA (L593754) 是一种具有口服活性的 TRPP3 通道抑制剂，IC₅₀ 为 10.5 μM。EIPA 可通过抑制 Na⁺/H⁺-exchanger 3 (NHE3) 来促进自噬 (autophagy)。EIPA 也抑制巨胞饮作用 (macropinocytosis)。EIPA 可用于炎症和癌症的研究，如胃癌、结肠癌、胰腺癌。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  GPCR/G Protein  |  Autophagy  |  Immunology/Inflammation

作用靶点：TRP Channel  |  Prostaglandin Receptor  |  Autophagy  |  COX  |  Na+/H+ Exchanger (NHE)

In Vitro: EIPA (100 μM, 30 min) suppresses TRPP3-mediated Ca²⁺ uptake in X. laevis oocytes.
EIPA hydrochloride (10-100 μM) reversibly inhibits the basal Na⁺ current (IC₅₀: 19.5 μM).
?EIPA (300 μM, 6h) enhances autophagy through NHE3 (Na⁺/H⁺-exchanger 3) in IEC-18 cells.
EIPA (20 μM, 2 h) blocks macropinocytosis-mediated uptake of CA-PZ massively entry in HT-29 cells and MIA PaCa-2 cells.
EIPA (30 μM, 3h) attenuates Zinc/Kainate toxicity by decreasing Zn²⁺ entry in cerebellar granule neurons.
EIPA (5-100 μM, 48h) suppresses proliferation of MKN28 cells through up-regulation of p21 expression.
EIPA (3 μM, 6 h) inhibits the LPS-induced increase in the level of COX-2 protein.

In Vivo: EIPA (Intravenous injection, 1 mg/kg) dose-dependently attenuates the I/R (Ischemia/reperfusion)-induced renal dysfunction in ddY strain mice.
EIPA (oral administration, 10 mg/kg) inhibits LPS-induced inflammation in air pouch-type LPS-induced inflammation model.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Angiogenesis-Related Compound Library  |  Mechanoreceptors Compound Library  |  Anti-Colorectal Cancer Compound Library   |  Antidepressant Compound Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Cell Death Library  |  Ion Channel Compound Library  |  Rosiglitazone  |  Prostaglandin E2  |  Capsaicin  |  Acetaminophen  |  GsMTx4  |  Indomethacin  |  Celecoxib  |  Probenecid  |  Aspirin  |  Diphenyleneiodonium chloride  |  2-Aminoethyl diphenylborinate  |  Amiloride hydrochloride  |  GSK1016790A  |  Monensin sodium salt  |  Oxidopamine hydrobromide  |  Capsazepine  |  Deferiprone  |  Prostaglandin E1  |  Diclofenac  |  HC-067047  |  HC-030031  |  Gallic acid  |  Ibuprofen  |  ML-SA1  |  Tranilast  |  GSK2193874  |  Adenosine 5′-diphosphoribose sodium  |  Catechin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds