Biodragon博奥龙WB明星产品B8008现货促销Tub

Biodragon博奥龙WB明星产品B8008现货促销Tubulin beta-3(12Z6) Rabbit Monoclonal Antibody博奥龙Biodragon独家总代理19121878899上海睿安生物

产品基本信息

• 产品货号B8008
• 别名TUBB3;TUBB4;Tubulin beta-3 chain;Tubulin beta-4 chain;Tubulin beta-III
• 产品名称Tubulin beta-3 (12Z6) Rabbit Monoclonal Antibody
• 类别抗体产品
• 基因名称TUBB3
• 蛋白名称Tubulin beta-3 chain
• 推荐应用WB,ELISA
• 反应种属Human,Mouse (predicted: Rat)
• 存储缓冲液PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID10381
• Human Swissprot No.Q13509
• Mouse Gene ID22152
• Mouse Swissprot No.Q9ERD7
• Rat Gene ID246118
• Rat Swissprot No.Q4QRB4
• 免疫原Synthesized peptide derived from human protein. AA range:400-450
• 特异性endogenous
• 稀释度WB 1:500-2000, ELISA 1:20000
• 参考分子量50kDa
• 预测分子量50kDa
• 运输及保存条件Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主Monoclonal Rabbit IgG1, Kappa
• 背景介绍tubulin beta 3 class III(TUBB3) Homo sapiens This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010],
• 细胞定位Cytoplasm, cytoskeleton . Cell projection, growth cone . Cell projection, lamellipodium . Cell projection, filopodium .
• 表达Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.
• 功能domain:The highly acidic C-terminal region may bind cations such as calcium.,function:Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,polymorphism:Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2 (SHEP2) [MIM:266300]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator.
• 纯化Protein A

Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with β-actin Rabbit Monoclonal Antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1:A431 Lane 2:HEK293 Predicted band size: 50kDa Observed band size: 50kDa