Z-VAD(OMe)-FMK

概述

• 产品名称
  Z-VAD(OMe)-FMK
• 描述
  Cell permeable， irreversible pan-caspase inhibitor
• 别名
  • Z-VAD-FMK (cell permeable)
• 生物学描述
  A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
• 纯度
  > 90%

性能

• 分子量
  467.49
• 化学结构
  
• 分子式
  C₂₂H₃₀FN₃O₇
• CAS编号
  187389-52-2
• 序列
  VAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Asp-3 = Asp(OMe))
• PubChem识别号
  5497173
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 20 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  FCC(=O)C(CC(=O)OC)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C
• 来源

  Synthetic