Apamin

概述

• 产品名称
  Apamin
• 描述
  Blocker of small conductance Ca²⁺-activated K⁺ channels
• 生物学描述
  Peptide neurotoxin that naturally occurs in Apis mellifera bee venom. Blocks small conductance Ca²⁺ activated K⁺ channels (SK). Selective for KCa2.1-2.3 (SK1-3) isoforms. Blocks hSK1, rSK2 and liver rSK3 (IC₅₀values are 8 nM, 83 pM and 0.6 nM, respectively).
• 纯度
  > 95%

性能

• 分子量
  2027.35
• 化学结构
  
• 分子式
  C₇₉H₁₃₁N₃₁O₂₄S₄
• CAS编号
  24345-16-2
• 序列
  CNCKAPETALCARRCQQH (Modifications: C-terminal amide; Disulfide bonds: 1-11, 3-15)
• PubChem识别号
  16218850
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in water
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• 来源

  Synthetic