Purvalanol B

概述

• 产品名称
  Purvalanol B
• 描述
  CDK2 inhibitor
• 生物学描述
  Potent CDK2 inhibitor, displaying an IC₅₀ against the complex of CDK2-cyclin A of 6 nM. Shows selectivity over a range of other protein kinases including protein kinase C, Raf kinase, and casein kinase2.
• 纯度
  > 95%

性能

• 化学名称
  4-[2-((R)-1-Hydroxy-3-methylbutan-2-ylamino)-9-isopropyl-9H-purin-6-ylamino]-2-chlorobenzoic acid
• 分子量
  432.91
• 化学结构
  
• 分子式
  C₂₀H₂₅ClN₆O₃
• CAS编号
  212844-54-7
• PubChem识别号
  448991
• 存放说明
  Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in 1 eq. NaOH to 100 mM (with warming)
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  O=C(O)c1ccc(cc1Cl)Nc3nc(nc2c3ncn2C(C)C)N[C@@H](CO)C(C)C
• 来源

  Synthetic