HA-1077 (Fasudil)

概述

• 产品名称
  HA-1077 (Fasudil)
• 描述
  ROCK2 inhibitor
• 别名
  • Fasudil
• 生物学描述
  ROCK2 inhibitor (IC₅₀ = 1.9 µM). Also shown to inhibit PRK2 (IC₅₀ = 4 µM), MSK1 (IC₅₀ = 5 µM), Rsk2 (IC₅₀ = 15 µM), PKA, p70 S6 Kinase, CaM Kinase and MLCK. Calcium antagonist and vasodilator.
  
  Also available in simple stock solutions (ab146700) - add 1 ml of water to get an exact, ready-to-use concentration.
• 纯度
  > 98%

性能

• 化学名称
  1-(5-Isoquinolinylsulfonyl) hydrochloride
• 分子量
  327.83
• 化学结构
  
• 分子式
  C₁₄H₁₇N₃O₂S.HCl
• CAS编号
  103745-39-7
• PubChem识别号
  163751
• 存放说明
  Store at Room Temperature. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in water to 100 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  Cl.O=S(=O)(c2cccc1cnccc12)N3CCCNCC3
• 来源

  Synthetic