Thioflavin T硫黄素T,2390-54-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Thioflavin T

CAS No. : 2390-54-7

MCE 国际站：Thioflavin T

产品活性：Thioflavin T 是一种阳离子 Benzothiazole 染料，在组织切片中与淀粉样蛋白结合后荧光强度增强。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.

相关产品：DAPT  |  β-Amyloid (25-35)  |  β-Amyloid (1-42), human TFA  |  FPS-ZM1  |  Colivelin TFA  |  Rutin  |  Azeliragon  |  20(S)-Ginsenoside Rg3  |  Ginsenoside Rg1  |  β-Amyloid (1-42), (rat/mouse)  |  Tolcapone  |  Geniposide  |  Methoxy-X04  |  Emrusolmin  |  Semagacestat  |  Ginsenoside Re  |  Aducanumab  |  Notoginsenoside R1  |  Bavachinin  |  Licochalcone B  |  Hoechst 34580 tetrahydrochloride  |  β-Amyloid (1-40)  |  Direct Blue 1  |  Leucomethylene blue mesylate  |  Valiltramiprosate  |  Glimepiride  |  Hematoxylin  |  Chemerin-9 (149-157) (TFA)  |  RAGE antagonist peptide TFA

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds