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- 2025年12月05日
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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
189744-94-3
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥427.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥388.0 |
| 规格： | 10 mg | 产品价格： | ￥570.0 |
| 规格： | 25 mg | 产品价格： | ￥980.0 |
| 规格： | 50 mg | 产品价格： | ￥1416.0 |
| 规格： | 100 mg | 产品价格： | ￥2340.0 |
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Ro 10-5824 dihydrochloride
CAS No. : 189744-94-3
MCE 国际站：Ro 10-5824 dihydrochloride
产品活性：Ro 10-5824 dihydrochloride 是一种选择性的 dopamine D4 受体 部分激动剂，Ki 值为 5.2 nM。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Dopamine Receptor
In Vitro: RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level.
In Vivo: Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.
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