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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(Z)-Hispidol
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
5786-54-9
- 规格：
10 mM * 1 mL/100 mg/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2377.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | 询价 |
| 规格： | 1 mg | 产品价格： | ￥1136.0 |
| 规格： | 5 mg | 产品价格： | ￥2500.0 |
| 规格： | 10 mg | 产品价格： | ￥3500.0 |
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Hispidol
CAS No. : 5786-54-9
MCE 国际站：Hispidol
产品活性：Hispidol ((Z)-Hispidol) 具有研究炎症性肠病的潜力，能够抑制 TNF-α 诱导的单核细胞对结肠上皮细胞的粘附，IC50 值为 0.50 µM。
研究领域：Apoptosis
作用靶点：TNF Receptor
In Vitro: Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.
In Vivo: The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.
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