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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
220119-17-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥532.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥388.0 |
| 规格： | 10 mg | 产品价格： | ￥628.0 |
| 规格： | 25 mg | 产品价格： | ￥1300.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥3100.0 |
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Selamectin
CAS No. : 220119-17-5
MCE 国际站：Selamectin
产品活性：Selamectin，一种半合成的大环内酯，是一种抗寄生虫剂和驱虫剂。Selamectin 激活神经元和咽肌中的谷氨酸门控氯离子通道 (glutamate-gated chloride channels)，以预防恶丝虫，淋巴丝虫和线虫感染。Selamectin 还是一种有效的 P-糖蛋白 (P-glycoprotein) 底物和抑制剂，IC50 为 120 nM。
研究领域：Anti-infection | Membrane Transporter/Ion Channel
作用靶点：Parasite | Chloride Channel | P-glycoprotein | Bacterial
In Vitro: The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.
In Vivo: A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
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