Eniporide,211813-86-4

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Eniporide hydrochloride

CAS No. : 211813-86-4

MCE 国际站：Eniporide hydrochloride

产品活性：Eniporide hydrochloride (EMD-96785 hydrochloride)是有效地 Na+/H+ 交换抑制剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Na+/H+ Exchanger (NHE)

In Vitro: There is no significant effects of the Na⁺/H⁺ exchange inhibitor eniporide on cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest.

In Vivo: In stage 1, the administration of 100 mg and 150 mg eniporide results in smaller infarct sizes, especially in the angioplasty group. In contrast, in stage 2 there is no difference in the enzymatic infarct size between the three groups. Overall there is no effect of eniporide on clinical outcome (death, cardiogenic shock, heart failure, life-threatening arrhythmias). However, there is a significant reduction of the incidence of heart failure in patients reperfused late (>4 h).

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