R-IMPP,2133832-83-2

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R-IMPP

CAS No. : 2133832-83-2

MCE 国际站：R-IMPP

产品活性：R-IMPP (PF-00932239) 是一种 PCSK9 的抗分泌活性分子 (IC₅₀=4.8 μM)，其靶向 80S 核糖体抑制 PCSK9 蛋白翻译。

研究领域：Metabolic Enzyme/Protease

作用靶点：Ser/Thr Protease

In Vitro: R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes.

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