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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
PhTx 74 dihydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1227301-51-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥893.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2800.0 |
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Philanthotoxin 74 dihydrochloride
CAS No. : 1227301-51-0
MCE 国际站：Philanthotoxin 74 dihydrochloride
产品活性：Philanthotoxin 74 dihydrochloride (PhTx 74) 是 AMPAR 的拮抗剂; 抑制 GluR3 和 GluR1 的 IC50 值分别为263和296 nM。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：iGluR
In Vitro: Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2.
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文献和实验39 4.06 3.47 3.13 2.91 2.75 2.63 2.54 2.46 2.40 2.30 2.19 2.08 1.95 1.81 1.65 39 40 4.05 3.46 3.13 2.90 2.74 2.62 2.53 2.45 2.39 2.29 2.18 2.07 1.94 1.80 1.64 40 42 4.03 3.45 3.11 2.89 2.73 2.61 2.51 2.43 2.37 2.27 2.16 2.05 1.92 1.78 1.61 42
数字表 编号 1 2 3 5 6 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 1 03 47 43 73 86 36 96 47 36 61 46 98 63 71 62 33 26 16 80 45 60 11 14 10 95 2 97 74 24 67 62 42 81 14 57 20 42 53 32 37 32 27 07 36 07 51 24 51 79 89 73 3 16 76 62 27 66 56 50 26
2.54 12 13 4.67 3.81 3.41 3.18 3.03 2.92 2.83 2.77 2.71 2.67 2.60 2.55 2.51 2.48 2.46 13 14 4.60 3.74 3.34 3.11 2.96 2.85 2.76 2.70 2.65 2.60 2.53 2.48 2.44 2.41 2.39 14 15 4.54 3.68 3.29 3.06 2.90 2.79 2.71 2.64 2.59 2.54 2.48 2.42 2.38 2.35 2.33 15
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