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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month
- 英文名：
GLP-2 (human);Glucagon-like peptide 2 (human)
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
223460-79-5
- 规格：
500 μg/1 mg/5 mg
| 规格： | 500 μg | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2500.0 |
| 规格： | 5 mg | 产品价格： | ￥9500.0 |
GLP-2(1-33)(human)
产品活性：GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to the GLP-2 receptor and stimulate the growth of intestinal epithelium.
研究领域：GPCR/G Protein
作用靶点：Glucagon Receptor
In Vitro: GLP-2-treated group demonstrates a 518±22% increase (P<0.05) in mucosal IGFBP-4 mRNA levels as compare with vehicle-treated controls. Because the mucosal expression of IGFBP-4 transcripts is found to be very low relative to that of the whole intestine, FRIC cultures are used as an in vitro model of the entire intestine. FRIC cultures have previously been established to express a functional GLP-2 receptor (GLP-2R) that displays a cAMP response, as well as enhances IGF-1 mRNA expression and IGF-1 secretion in response to GLP-2 treatment. When incubates with GLP-2 (10−8 M) for 2 hours, IGFBP-4 mRNA expression in the FRIC cultures is also found to be increased, by 40.8±15.2% (P<0.05), compare with vehicle-treated cells[1].
In Vivo: GLP-2 quickly increases apoB48 mass in the TRL fraction of plasma, which is indicative of chylomicron number, and this is blocked by L-NAME. GLP-2 treatment alone increases postprandial TRL-lipids (slope 3.65±0.73×10−3 g/L/min vs 1.63±0.28×10−3 g/L/min, GLP-2 vs control), and this effect is completely mitigated by L-NAME pretreatment (slope 3.67±0.15×10−4 g/L/min). The GLP-2-induced rise in TRL-apoB48 occurres within 30 minutes and precedes the rise in TRL-TG. GLP-2 acutely increases plasma tritium levels (slope, 1.66±0.25×102 dpm/mL/min vs 1.11±0.17×102 dpm/mL/min, GLP-2 vs control)[2].
相关产品：Bioactive Compound Library Plus | Exendin-4 | Liraglutide | Glucagon | Adomeglivant | Avexitide | MK 0893 | GLP-1(7-36) Acetate | Lixisenatide | GLP-1(7-37) | LGD-6972 | Taspoglutide | Semaglutide TFA | GLP-1 moiety from Dulaglutide | GLP-1 receptor agonist 1 | Glucagon receptor antagonists-1 | GRA Ex-25 | BETP | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | GLP-1 receptor agonist 2 | GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | PF-06291874 | Glucagon receptor antagonists-2 | HAEGTFT | HAEGTFTSD | HAEGTFTSDVS | KQMEEEAVRLFIEWLKNGGPSSGAPPPS
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文献和实验: 这个抗体是非磷酸化的抗体non-phospho-antibody ，33 代表的是基因位点 感觉不应该说“33 代表的是基因位点”，准确的说是指：该抗体的免疫原是合成非磷酸化的β-Catenin的33位丝氨酸附近的多肽。 Anti β-Catenin (Ab-33) Immunogen：Synthesized non-phosphopeptide derived from human β-Catenin
Exploring Human Metabolites Using the Human Metabolome Database
, J.S., Bocchini, C.A., and McKusick, V.A. 2005. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33:D514‐D517.
Freeze storage of human embryonic stem (hES) cells has not proven effective using the methods employed for mouse ES (mES) cells, while rhesus ES (rhES) cells are only modestly effectively frozen using common mES cell methods. Because human
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