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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
13153-27-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1342.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1220.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥4200.0 |
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NBTGR
CAS No. : 13153-27-0
MCE 国际站：NBTGR
产品活性：NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 Ki 值为70 nM。
研究领域：Others
作用靶点：Others
In Vitro: A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides.
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