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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
175140-00-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥657.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥399.0 |
| 规格： | 5 mg | 产品价格： | ￥915.0 |
| 规格： | 10 mg | 产品价格： | ￥1457.0 |
| 规格： | 25 mg | 产品价格： | ￥2768.0 |
| 规格： | 50 mg | 产品价格： | ￥4153.0 |
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CP 376395
CAS No. : 175140-00-8
MCE 国际站：CP 376395
产品活性：CP 376395 是一种有效的选择性的，可透过大脑的促肾上腺皮质激素释放因子 1 (CRF1) 受体拮抗剂。
研究领域：GPCR/G Protein
作用靶点：CRFR
In Vitro: CP 376395 fully antagonizes oCRF-stimulated adenylate cyclase activity in rat cerebral cortex and at human CRF1 receptors with an apparent Ki value of 12 nM, indicating antagonist functional activity. It is highly selective for the human CRF1 receptor subtype; affinity for the CRF2 receptor is >10000 nM. It shows affinities greater than 1 µM against 40 neurotransmitter receptor and ion channels.
In Vivo: CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Endocrinology Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | R121919 | Antalarmin hydrochloride | Verucerfont | Cortagine | NBI-27914 | Antisauvagine-30 TFA | CRF, bovine TFA | Pexacerfont | Urocortin, human | DMP 696 | Urocortin III, mouse TFA | α-Helical CRF(9-41) | Stressin I TFA | [DPro5] Corticotropin Releasing Factor, human, rat TFA | NVS-CRF38 | Sauvagine TFA | Tildacerfont | Urocortin, rat | Urotensin I | (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) | (Tyr0)-Urocortin, rat | a-Helical Corticotropin Releasing Factor (12-41) | a-Helical Corticotropin Releasing Factor (9-41) | BMS-665053
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文献和实验在肿瘤研究、免疫治疗等科研领域，组织样本 ELISA 检测是量化细胞因子、验证疗法疗效的核心手段。实验成败关键在于样本前处理的裂解质量、蛋白定量准确性及标准化操作，选对工具并遵循规范流程，能让数据可信度大幅提升。爱必信组织 / 细胞裂解液（多因子检测，货号 abs9225）搭配 BCA 蛋白定量试剂盒（abs9232），成为组织样本的黄金CP，助力科研人员精准突破实验瓶颈。 一、核心工具：优质裂解液奠定实验基础 组织样本成分复杂，普通裂解液含 SDS、NP40 等去垢剂，易干扰细胞因子检测。爱
Isolation of CP43 and CP47 Photosystem II Proximal Antenna Complexes From Plants
A single-column method to purify the CP43 and CP47 pigment-protein complexes of photosystem (PS)II from higher plants is presented. To validate the isolation procedure, three different species were used (Spinacea oleracea, Beta vulgaris
Isolation and Purification of CP43 and CP47 Photosystem II Proximal Antenna Complexes from Plants
A method to isolate and purify CP43 and CP47 pigment–protein complexes from Photosystem (PS) II of higher plants is presented. The method has been developed in spinach, but it may also be valid for other plant species, since there is high
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