- 询价
- 江蓝纯
- A108439
- 2025年07月14日
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- 详细信息
- 技术资料
- 保质期：
两年
- 英文名：
Azelaic acid
- 库存：
99
- 供应商：
江蓝纯
- CAS号：
123-99-9
属性
| 敏感性 | 对湿度敏感 |
| 折光率 | 1.4303 |
| 密度 | 0.8210 |
| 熔点 | 109-111°C |
| 沸点 | 286°C |
| 溶解性 | Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol. |
| 存贮条件 | 密封保存。 |
描述
| 产品介绍 | Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. |
| 别名 | 杜鹃花酸;1,7-壬二酸;庚烷-1,7-二羟酸;王二酸;1,7-庚二甲酸;;Nonanedioic acid; 1,7-heptanedicarboxylic acid; |
| 应用 | An antiinflammatory compound |
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壬二酸 99%
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