Human Lung Fibroblasts (HLF), or Pulmonary Fibroblasts, constitutes main portion of lung interstitium. They play an important role in maintaining lung homeostasis and ventilation. HLF mainly responsible for extracellular matrix (ECM) synthesis and remodeling. Pulmonary fibroblasts display spindle-shaped morphology and characteristic long branching process and gap junction. They are the central mediator of cellular migration and differentiation in wound healing upon injury and chronic inflammation. Abnormal lung fibroblast growth and ECM accumulation are associated with fibrotic disease such as hypoxia-induced pulmonary hypertension and idiopathic pulmonary fibrosis (IPF). The essential role of fibroblast cells in lung fibrosis makes it ideal therapeutic and pathological target. 人肺动脉成纤维细胞(HLF)或肺动脉成纤维细胞是肺间质的主要组成部分。它们在维持肺内稳态和通气方面起着重要作用。HLF主要负责细胞外基质(ECM)的合成和重构。肺成纤维细胞呈梭形形态,具有明显的长分枝和间隙连接特征。在创伤愈合和慢性炎症中,它们是细胞迁移和分化的中心中介。异常的肺成纤维细胞生长和ECM积累与纤维化疾病有关,如缺氧诱导的肺动脉高压和特发性肺纤维化(IPF)。成纤维细胞在肺纤维化中的重要作用使其成为理想的治疗和病理靶点.
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Application
For research use only Human lung fibroblasts provide an ideal model for studying lung function and pathology. They can be used to model lung disorders, infections and inflammations. Pulmonary fibroblast has also been used in various studies in gene expression pattern, biomarker identification, drug screening and stem cell research.
Key Features
-Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results