重组小鼠SHH(C25II) 分子生物学试剂

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北京百奥莱博专业生产供应重组小鼠SHH(C25II) 分子生物学试剂，我公司销*(代"售")全品类的分子生物学试剂，价格优惠，欢迎广大科研工作者垂询订购。

名称：重组小鼠SHH(C25II) 分子生物学试剂
品牌：百奥莱博
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse Sonic Hedgehog
产地：国产|进口
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Cys25-Gly198(Cys25Ile-Ile)表达纯化得来。

SHH(C25II)质量控制：＞95%(还原性SDS-PAGE)

SHH(C25II)制剂：冻干品

SHH(C25II)保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

SHH(C25II)复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于SHH(C25II)：
Mouse Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases.Mouse Shh is synthesized as a 437 aa precursor that contains a 24 aa signal sequence and a 413 aa mature region. The mature region is autocatalytically processed into a nonglycosylated, 20 kDa, 174 aa N­terminal fragment (Shh­N), and a catalytic­processing,glycosylated, 34 kDa, 239 aa C­terminal fragment. The 20 kDa Shh­N fragment is the core of the active hedgehog molecule. Mouse Shh­N is 99%, 98%, and 100% aa identical to human, rat and gerbil Shh­N, respectively.

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重组小鼠SHH(C25II) 分子生物学试剂关键词：重组小鼠C25II,重组小鼠SHH,重组小鼠SHH蛋白,重组SHH,JN1209

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重组小鼠SHH(C25II) 分子生物学试剂关键词：重组小鼠C25II,重组小鼠SHH,重组小鼠SHH蛋白,重组SHH,JN1209


·重组小鼠PD-1(程序性细胞死亡蛋白1)
编号：JN1894
英文名称：Recombinant Mouse Programmed Cell Death Protein 1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167在C端带有Fc标签。

PD-1质量控制：＞95%(还原性SDS-PAGE)

PD-1制剂：冻干品

PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于PD-1：
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.

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