关于GDNF: Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. Mutations in this gene may be associated with Hirschsprung disease.
·重组人CD320(TCblR)(8D6A) 编号:JN1885 英文名称:Recombinant Human Transcobalamin II Receptor 规格:10μg|50μg|500μg|1mg 本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ser36-Val231在C端带有Fc标签。
关于CD320/TCblR/8D6A: CD320 antigen is also known as 8D6 antigen,FDC-signaling molecule 8D6,Transcobalamin receptor and 8D6A.It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. CD320 can augments the proliferation of plasma cells precursors generated by IL-10. CD320 also founctions a receptor for the cellular uptake of transcobalamin bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) whichis a metabolic disorder.
·重组人OBFC1(含寡核苷酸结合折叠域蛋白1) 编号:JN1006 英文名称:Recombinant Human Oligosaccharide-Binding Fold-Containing Protein 1 规格:10μg|50μg|500μg|1mg 本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Phe368在N端含有His标签。
关于OBFC1: CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.