名称:重组人芳基硫*(代"酸")酯酶A(芳香基硫*(代"酸")酯酶A)(ARSA)价格 英文名:Recombinant Human Arylsulfatase A 编号:JN0704 产地:国产|进口 品牌:百奥莱博 规格:10μg|50μg|500μg|1mg 本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Arg19-Ala507在C端含有His标签。
ARSA质量控制:>95%(还原性SDS-PAGE)
ARSA制剂:液体
ARSA保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于ARSA: Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity.
·重组人Gankyrin蛋白(癌性锚蛋白重复序列) 编号:JN1952 英文名称:Recombinant Human Gankyrin 规格:10μg|50μg|500μg|1mg 本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Gly226表达纯化得来。
Gankyrin质量控制:>95%(还原性SDS-PAGE)
Gankyrin制剂:液体
Gankyrin保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于Gankyrin: Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
关于NRG1: Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is asingle-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
·重组人HSPB8(热休克蛋白β8) 编号:JN1217 英文名称:Recombinant Human Heat shock protein beta-8 规格:10μg|50μg|500μg|1mg 本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Thr196在C端含有His标签。
HSPB8质量控制:>95%(还原性SDS-PAGE)
HSPB8制剂:液体
HSPB8保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于HSPB8: Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity,appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.