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- IL-6
- 2026年01月12日
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| Source | E.coli |
| Description | Recombinant Human Interleukin-6 is produced by our E.coli expression system and the target gene encoding Pro29-Met212 is expressed. |
| Names | Interleukin-6, IL-6, B-Cell Stimulatory Factor 2, BSF-2, CTL Differentiation Factor, CDF, Hybridoma Growth Factor, Interferon Beta-2, IFN-Beta-2, IL6, IFNB2 |
| Accession # | P05231 |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 5.0. |
| Shipping | The product is shipped at ambient temperature. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Biological Activity | ED50 is less than 0.1 ng/ml. Specific Activity of 5.0 x 10^7 IU/mg. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
| Amino Acid Sequence |
PVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLP KMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKA KNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
|
| Background | Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro. |
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文献和实验猴白细胞介素 - 6（ IL- 6） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定猴血清，血浆及相关液体样本中 白细胞介素-6（IL-6） 含量。 实验原理 ： 本试剂盒应用 双抗体 夹心法测定 标本 中 猴白细胞介素 - 6（ IL- 6） 水平。用纯化的 猴白细胞介素 - 6（ IL- 6）抗体 包被微孔板，制成固相 抗 体，往包被 单抗 的微孔中依次
白细胞介素 IL-6 IL-6主要产生细胞：单核细胞、巨噬细胞、成纤维细胞、T细胞、内皮细胞 IL-6氨基酸数目：186 IL-6分子质量(kDa)：19-28 IL-6受体：CD126；CD130 IL-6主要生物学活性：刺激T细胞、B细胞、杂交瘤细胞和干细胞增殖；促进B细胞产生Ig；促进CTL、NK、干细胞和巨核细胞分化
一、用途本试剂盒用于定量检测大鼠血清中的IL-6的浓度。二、原理本试剂盒采用双抗夹心ELISA法。抗大鼠IL-6单抗包被于酶标板上，大鼠标本中的IL-6会与单抗结合。加入生物素化的抗大鼠IL-6（二抗），它将与结合在单抗上的大鼠IL-6结合而形成免疫复合物，未结合的将被洗去。辣根过氧化物酶标记的Streptavidin 将与二抗的生物素结合，多余的物质会被洗掉。加入TMB显色。大鼠IL-6的浓度与OD(450nm)成正比。三、试剂盒组成酶标板(Coated Wells)48wellsAnti
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