NFκB-p65 单克隆抗体

Western Blot（WB）已验证样本:Hela,293T,HepG2
免疫组织化学（IHC）已验证样本:Mouse hippocampus

WB 1:1000-3000, IHC 1:100-1:300, IP 1:100-1:300

Monoclonal

IgG

Synthetic Peptide

NFkB p65

Avian reticuloendotheliosis viral (v rel) oncogene homolog A;MGC131774;NF kappa B p65delta3;NFKB3;Nuclear Factor NF Kappa B p65 Subunit;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B cells 3;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;OTTHUMP00000233473;OTTHUMP00000233474;OTTHUMP00000233475;OTTHUMP00000233476;OTTHUMP00000233900;p65;p65 NF kappaB;p65 NFkB;relA;TF65;Transcription factor p65;v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65));V rel avian reticuloendotheliosis viral oncogene homolog A;v rel reticuloendotheliosis viral oncogene homolog A (avian);V rel reticuloendotheliosis viral oncogene homolog A;nuclear factor of kappa light polypeptide gene enhancer in B cells 3;p65抗体

Q04206

60kDa

65kDa

Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalized with RELA in the nucleus upon TNF-alpha induction.

1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Protein A purification

Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Neuroscience; Signal Transduction

Clone:9B4

Unconjugated

Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel,are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.