手机验证
P53 Monoclonal Antibody_货号:E-AB-22015_单克隆抗体
P53 Monoclonal Antibody
WB;IHC-p;IF
Mouse
Human
12个月
E-AB-22015
科研级别
999
武汉伊莱瑞特生物科技股份有限公司
Unconjugated
Monoclonal
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
液体
IgG
120μL/60μL/20μL
规格: | 120μL | 产品价格: | ¥2310.0 |
---|---|---|---|
规格: | 60μL | 产品价格: | ¥1420.0 |
规格: | 20μL | 产品价格: | ¥580.0 |
Verified Samples |
Verified Samples in WB:293T
Verified Samples in IHC:Human colon cancer, Verified Samples in IF:Hela |
Dilution |
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:200
|
Clonality |
Monoclonal
|
Isotype |
IgG
|
Immunogen |
Synthetic Peptide
|
Abbre |
p53
|
Synonyms |
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;FLJ92943;LFS1;Mutant tumor protein 53;p53;p53 tumor suppressor;P53;Phosphoprotein p53;Tp53;Transformation related protein 53;TRP53;Tumor protein 53;Tumor protein p53;Tumor suppressor p53抗体
|
Swissprot |
P04637
|
Calculated MW |
44kDa
|
Observed MW |
53kDa
|
Cellular Localization |
Cytoplasm; Cytoplasm. Nucleus. Nucleus>PML body. Endoplasmic reticulum. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2; Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli; Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells; Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm; Nucleus. Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4 and Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cytoplasm following cell stress.
|
Tissue Specificity |
Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
|
Concentration |
1 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
|
Purification Method |
Protein A purification
|
Research Areas |
Cancer; Cell Biology; Epigenetics and Nuclear Signaling
|
Clone No. |
Clone:1H4
|
Conjugation |
Unconjugated
|
Background |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
|
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
自2012年第一篇引用文献问世,至2023年8月,Elabscience已协助各地科研工作者发表超13,000篇SCI文献,包括行业顶/级期刊Nature Medicine, Nature, Cell, Signal Transduction and Targeted Therapy, Circulation, Molecular Cancer, Immunity, Advanced Materials等,总影响因子(IF)59472.59,其中IF≥30的文献超30篇,最高影响因子为66.849,发文单位包含北京大学、中国科学技术大学、浙江大学、斯坦福大学、耶鲁大学、柏林夏里特大学等国内外各大高校。
每年引用文献数量持续增长,保持逐年30%+高增长率,可以预见,Elabscience产品将帮助更多科研工作者发表高质量SCI论文。
文献详情查看>>>>