InVivoMab anti-mouse OX40L (CD

InVivoMAb anti-mouse OX40L (CD134L)是Bioxcell的一款热销产品，货号BE0033-1-25MG，规格是25MG，还有其他几种规格可供选择。欣博盛生物是Bioxcell授权一级代理，指定中国现货库存中心，如需购买该产品，或咨询产品技术问题，请联系我们。

The RM134L monoclonal antibody reacts with mouse OX-40L also known as CD134L. OX-40L is a 35 kDa member of the TNF superfamily that is expressed on activated B cells and antigen presenting cells. OX40L is the ligand for OX-40 (CD134). OX-40 signaling regulates both CD4 and CD8 T cell clonal expansion. It provides a costimulatory signal to an antigen-reacting naive T cells to prolong proliferation, as well as augment the production of several cytokines including IL-2. In vivo treatment with the RM134L antibody has been shown to inhibit the poly(I:C)/CD40 stimulated proliferation of CD4 T cells.

Specifications

Isotype    Rat IgG2b, κ
Recommended Isotype Control(s)    InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin
Recommended Dilution Buffer    InVivoPure pH 7.0 Dilution Buffer
Conjugation    This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen    Rat NRK-52E cells transfected with mouse OX40L
Reported Applications    in vivo blocking of OX40/OX40L signaling
in vitro OX40L neutralization
Formulation    PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin    <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity    >95%
Determined by SDS-PAGE
Sterility    0.2 µm filtration
Production    Purified from cell culture supernatant in an animal-free facility
Purification    Protein G
RRID    AB_1107594
Molecular Weight    150 kDa
Storage    The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

References

in vivo blocking of OX40/OX40L signaling
Gattringer, M., et al. (2015). "Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen" Clin Exp Allergy. doi : 10.1111/cea.12661. 

in vivo blocking of OX40/OX40L signaling
Baeyens, A., et al. (2015). "Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context" J Immunol 194(3): 999-1010.

in vivo blocking of OX40/OX40L signaling
Welten, S. P., et al. (2015). "The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion" Elife 4. doi : 10.7554/eLife.07486.