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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
CD46 antibody | JM6C11
- 抗体英文名：
MOUSE ANTI PIG CD46
- 浓度：
IgG concentration 1.0 mg/ml
- 应用范围：
F
- 宿主：
Mouse
- 适应物种：
Pig
- 保质期：
自发货之日起 12 个月
- 目录编号：
JM6C11
- 供应商：
伯乐生命医学产品（上海）有限公司
- 标记物：
Purified
- 克隆性：
Monoclonal Antibody
- 形态：
Purified IgG - liquid
- 亚型：
IgG1
- 免疫原：
Porcine peripheral blood mononuclear cells
- 规格：
0.1 mg
小鼠抗猪CD46抗体，克隆号JM6C11是一款用于检测猪CD46抗原的单克隆抗体，适用于流式细胞术等应用。该抗体靶向猪的CD46（膜辅因子蛋白，MCP），这是一种在所有外周血细胞上表达的分子量约45-65 kDa的跨膜糖蛋白。克隆JM6C11能够抑制CD46的辅因子功能，可用于相关免疫学和细胞生物学研究。
小鼠抗猪CD46抗体，克隆号JM6C11 识别猪CD46，也称为膜辅因子蛋白（MCP）。CD46是一种在所有外周血细胞上表达的约45-65 kDa的单次跨膜I型糖蛋白。
小鼠抗猪CD46抗体，克隆号JM6C11能够抑制功能性MCP辅因子活性，这通过抑制C3 α链的裂解来测定（Pérez De La Lastra 等人 1999）。
小鼠抗猪CD46抗体，克隆号JM6C11能够抑制功能性MCP辅因子活性，这通过抑制C3 α链的裂解来测定（Pérez De La Lastra 等人 1999）。
储存信息
本产品在环境温度下运输。建议收到后分装并储存于-20°C。解冻后，根据需要分装样品。短期使用（最多4周）可将分装样品保存在2-8°C，其余分装样品储存于-20°C。
避免反复冻融，因为这可能导致抗体变性。不建议储存在无霜冰箱中。
避免反复冻融，因为这可能导致抗体变性。不建议储存在无霜冰箱中。
应用
据报道，本产品适用于以下应用。此信息源自我们实验室的测试、同行评审的出版物或原研者的个人交流。更多信息请参阅所示参考文献。有关一般实验方案建议，请访问 抗体实验方案 页面。
| 应用名称 | 已验证 | 最小稀释度 | 最大稀释度 |
|---|---|---|---|
| 流式细胞术 | ✓ | 1/10 |
若本产品未在特定技术中进行测试，这并不一定排除其在该技术中的使用。建议的工作稀释度仅供参考。建议用户在其自身系统中使用适当的阴性/阳性对照来确定产品的适用稀释度。
- 流式细胞术
- 使用10μl建议的工作稀释度在100μl体积中标记106个细胞。
FAQ
1. 这款抗体识别的靶点是什么？
这款抗体识别猪的CD46抗原，也称为膜辅因子蛋白（MCP）。
2. 该抗体已验证的应用有哪些？
根据产品信息，该抗体已验证可用于流式细胞术。
3. 产品应如何保存？
建议收到产品后分装并储存于-20°C。短期使用（最多4周）可保存于2-8°C，应避免反复冻融，也不建议储存在无霜冰箱中。
4. 该抗体在流式细胞术中如何使用？
建议使用10μl推荐的工作稀释度（最大稀释度1/10）在100μl体积中标记106个细胞。具体稀释比例建议用户根据自身实验体系进行优化。
Mouse anti Pig CD46 antibody, clone JM6C11 recognizes porcine CD46, also known as membrane cofactor protein (MCP). CD46 is a ~45-65 kDa single pass type 1 transmembrane glycoprotein expressed by all peripheral blood cells.
Mouse anti Pig CD46 antibody, clone JM6C11 inhibits functional MCP cofactor activity as measured by inhibition of cleavage of the α chain of C3 (Pérez De La Lastra et al. 1999).
Mouse anti Pig CD46 antibody, clone JM6C11 inhibits functional MCP cofactor activity as measured by inhibition of cleavage of the α chain of C3 (Pérez De La Lastra et al. 1999).
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | 1/10 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
References for CD46 antibody
- van den Berg, C.W. et al. (1997) Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP).
J Immunol. 158: 1703-9. - Haverson, K. et al. (2001) Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens.
Vet Immunol Immunopathol. 80: 5-23. - Pérez De La Lastra, J.M. et al. (1999) Epitope mapping of 10 monoclonal antibodies against the pig analogue of human membrane cofactor protein (MCP).
Immunology. 96: 663-70. - Dräger, C. et al. (2015) Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro.
Arch Virol. 160: 739-46.
Further Reading
- Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
Vet Res. 39: 54.
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小鼠抗猪CD46抗体，克隆号JM6C11
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