- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8℃
- 保质期:
见包装
- 英文名:
Paclitaxel
- 库存:
大量现货
- 供应商:
上海研谨生物
- CAS号:
33069-62-4
- 规格:
20mg
紫杉醇
分析标准品,HPLC≥98%
Paclitaxel
CAS号:33069-62-4
分子式:C47H51NO14
分子量:853.92
MDL:MFCD00869953
别名:泰素,紫素,特素 taxal;TAXOL;EMPAC;Onxal
|
货号 |
规格/参数/品牌 |
价格 |
货期 |
|
YJ-B21695-20mg |
分析标准品,HPLC≥98% |
¥200.00 |
现货 |
|
YJ-B21695-100mg |
分析标准品,HPLC≥98% |
¥550.00 |
现货 |
|
JS31470-500mg |
≥98% |
¥1100.00 |
现货 |
|
JS31470-1g |
≥98% |
¥2000.00 |
现货 |
|
JS31470-5g |
≥98% |
¥5250.00 |
现货 |
|
A10255-30mg |
分析标准品,含量99.0%,可溯源 |
¥550.00 |
现货 |
|
A10255-50mg |
分析标准品,含量99.0%,可溯源 |
¥700.00 |
现货 |
|
JT92424-1ml买5赠1 |
10mM in DMSO |
¥348.00 |
现货 |
产品介绍
Paclitaxel 是一种天然抗肿瘤药,可稳定微管蛋白 (tubulin) 的聚合。Paclitaxel 可导致有丝分裂停滞和诱导细胞凋亡 (apoptosis),最终导致细胞死亡。Paclitaxel 还可诱导细胞自噬 (autophagy)。
熔点:213-216℃
沸点:957.115 ℃ at 760 mmHg
比旋光度:-49.0°-55.0°(甲醇)
外观:白色结晶体粉末
溶解性:DMSO : 100 mg/mL (117.11 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
储存条件:2-8℃
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2. 马生军 刘建慧 马留纯 王颖 曹雪琴 罗建民.不同产地及生长年限曼地亚红豆杉中10-脱乙酰基巴卡亭Ⅲ、三尖杉宁碱、紫杉醇量的比较分析[J].中草药 2017 48(23):4979-4985.
1. 李昆太 彭卫福 周佳 等. 一株产紫杉醇的南方红豆杉内生菌的分离与鉴定[J]. 江西农业大学学报 2013 035(001):184-188.
紫杉醇是红豆杉属植物中的一种复杂的次生代谢产物, 也是目前所了解的惟一一种可以促进微管聚合和稳定已聚合微管的药物。同位素示踪表明, 紫杉醇只结合到聚合的微管上, 不与未聚合的微管蛋白二聚体反应。细胞接触紫杉醇后会在细胞内积累大量的微管,这些微管的积累干扰了细胞的各种功能,特别是使细胞分裂停止于有丝分裂期,阻断了细胞的正常分裂。
美国的“国家癌症研究中心”从太平洋紫杉(学名: Taxus brevifolia Nutt.)的树皮中萃取出紫杉醇(Paclitaxel 商品名 Taxol),发现它具有抗癌的效果,经过一连串的临床试验,民国七十八年正式制成制剂用来治疗卵巢癌与乳癌。由于它的治疗效果甚佳,使得太平洋紫杉被预言为「二十世纪对人类贡献最大的植物」。 不过太平洋紫杉生长缓慢,从树皮萃取紫杉醇的产量又甚低,以治疗一个卵巢癌病患需要二公克紫杉醇而言,就需要砍伐二到三棵 50 ~ 60 年生的太平洋紫杉
Theranostics | 空间代谢组学方法评估抗癌药物肿瘤靶向效率和瘤内分布异质性
在《Theranostics》期刊发表的题为“Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging”的研究成果,采用空气动力辅助解吸电喷雾离子化(AFADESI)技术和基于人工神经网络(ANN)的虚拟校正-定量质谱成像(VC-QMSI)方法,建立了针对紫杉醇及其衍生物前药的体内定量成像方法,为评估该类
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