LMP744,308246-52-8

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LMP744

CAS No. : 308246-52-8

MCE 国际站：LMP744

产品活性：LMP744 (MJ-III65) 是一种 DNA 嵌合剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: The GI₅₀ value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G₂ phases of the cell cycle.

In Vivo: LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

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