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雷帕霉素

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  • ¥350
  • Sigma
  • Sigma/上海
  • YJ-B20714-20mg
  • 2025年10月30日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃

    • 保质期

      见包装

    • 英文名

      Rapamycin

    • 库存

      大量现货

    • 供应商

      上海研谨生物/杭州研谨

    • CAS号

      53123-88-9

    • 规格

      20mg

    雷帕霉素

    分析标准品,HPLC≥99%

    Sirolimus

    CAS号:53123-88-9

    分子式:C51H79NO13

    分子量:914.18

    MDLMFCD00867594

    别名:西罗莫司;瑞帕霉素

    货号

    规格/参数/品牌

    价格

    货期

    YJ-B20714-20mg

    分析标准品,HPLC≥99%

    350.00

    现货

    YJ-B20714-50mg

    分析标准品,HPLC≥99%

    600.00

    现货

    YJ-B20714-200mg

    分析标准品,HPLC≥99%

    1300.00

    现货

    JS17098-50mg

    BR98%

    270.00

    现货

    JS17098-100mg

    BR98%

    350.00

    现货

    JS17098-500mg

    BR98%

    900.00

    现货

    JS17098-1g

    BR98%

    1200.00

    现货

    JS17098-5g

    BR98%

    3280.00

    现货

    JT88277-1ml

    10mM in DMSO

    649.00

    现货

     

    产品介绍

     Rapamycin (Sirolimus) (GMP) GMP 级别的Rapamycin (HY-10219)GMP 级别的小分子可用做细胞疗法中的辅助试剂。Rapamycin 是一种有效且特异性的 mTOR 抑制剂。 

    熔点:183-185℃

    沸点:973.017 ℃ at 760 mmHg

    比旋光度:D25 -58.2° (methanol)

    外观:黄色固体(类白色固体)

    溶解性:DMSO100mg/ml(需超声)

    敏感性:对热敏感

    储存条件:-20℃

    注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

     

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    图标文献和实验
    该产品被引用文献

    参考文献(45)

    45. [IF=5.4] Tong Xu et al."Buyang Huanwu Decoction Attenuates Arterial In-Stent Restenosis via Transforming Growth Factor Beta Receptor 1-Mediated Suppression of Neointimal Hyperplasia."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jul;:120244

    44. [IF=2.5] Fan Yan-jun et al."Colon Dialysis with Yishen Decoction Improves Autophagy Disorder in Intestinal Mucosal Epithelial Cells of Chronic Renal Failure by Regulating SIRT1 Pathway."Chinese Journal of Integrative Medicine.2025 May;:1-9

    43. [IF=4] Zhao Yuping et al."Effects of dual-functional surface design on properties of bioresorbable stent molded by 3D printing."POLYMER BULLETIN.2025 May;:1-21

    42. [IF=10.3] Bilin Zhao et al."Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP."ENVIRONMENT INTERNATIONAL.2025 Jan;195:109215

    41. [IF=4.9] Duan Jiangling et al."RAB37 suppresses the EMT, migration and invasion of gastric cancer cells by mediating autophagic degradation of β-catenin."CELLULAR ONCOLOGY.2024 Dec;:1-15

    40. [IF=4.8] Zhang Man-yu et al."Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats."INFLAMMATION RESEARCH.2025 Dec;74(1):1-19

    39. [IF=6] Yajing Li et al."Procyanidin A1 from Peanut Skin Exerts Anti-Aging Effects and Attenuates Senescence via Antioxidative Stress and Autophagy Induction."Antioxidants.2025 Mar;14(3):322

    38. [IF=3.4] Weili Cao et al."The role and mechanism of action of miR‑92a in endothelial cell autophagy."Molecular Medicine Reports.2024 Sep;30(3):1-12

    37. [IF=4.4] Xianli Lei et al."mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy."MEDIATORS OF INFLAMMATION.2024 Jul;2024(1):4233439

    36. [IF=5] Minglv Fang et al."Perillaldehyde alleviates polyQ-induced neurodegeneration through the induction of autophagy and mitochondrial UPR in Caenorhabditis elegans."BIOFACTORS.2024 Jul;:

    35. [IF=5.6] Yalin Xie et al."A novel photoreduction deposition induced AuNPs/COFs composite for SERS detection of macrolide antibiotics."TALANTA.2024 Nov;279:126547

    34. [IF=4.4] Dandan Wei et al."Effect of Compressive Modulus of Porous PVA Hydrogel Coating on the Preventing Adhesion of Polypropylene Mesh."MACROMOLECULAR BIOSCIENCE.2024 Jun;:2400112

    33. [IF=5.6] Chunliu Mi et al."Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1α accumulation in cancer cells."INTERNATIONAL IMMUNOPHARMACOLOGY".2024 May;133:112066

    32. [IF=7.9] Zhiqiang Feng et al."Liensinine sensitizes colorectal cancer cells to oxaliplatin by targeting HIF-1a to inhibit autophagy."PHYTOMEDICINE".2024 Apr;:155647

    31. [IF=6.1] Xiaoxue Fang et al."Puerarin Induces Macrophage M2 Polarization to Exert Antinonalcoholic Steatohepatitis Pharmacological Activity via the Activation of Autophagy."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY".2024;XXXX(XXX):XXX-XXX

    30. [IF=4.8] Lu-lu Han et al."Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling."Journal of Integrative Medicine-JIM.2024 Jan;:

    29. [IF=4] Liu Jingyu et al."Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats."MOLECULAR HUMAN REPRODUCTION.2023 Nov;:

    28. [IF=7] Yang Kai et al."NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway."Cell Death Discovery.2023 Oct;9(1):1-15

    27. [IF=14.903] Huiyang Wang et al."Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats."Acta Pharmaceutica Sinica B.2023 Mar;:

    26. [IF=5.999] Dandan Wei et al."Polypropylene composite hernia mesh with anti-adhesion layer composed of PVA hydrogel and liposomes drug delivery system."COLLOIDS AND SURFACES B-BIOINTERFACES.2023 Jan;:113159

    25. [IF=5.195] Peng Wei et al."Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress."JOURNAL OF ETHNOPHARMACOLOGY.2023 Mar;304:116095

    24. [IF=6.081] Huangrong Zhu et al."Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat."Frontiers in Cell and Developmental Biology.2022; 10: 971736

    23. [IF=6.543] Gong Wan et al."Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway."Oxidative Medicine and Cellular Longevity. 2022;2022:5410377

    22. [IF=4.677] Wang Hao et al."mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion."APOPTOSIS. 2022 Apr;:1-8

    21. [IF=1.892] Weiwei Zhao et al."High pathogenicity island is associated with enhanced autophagy in pathogenic Escherichia coli HPI - infected macrophages."Res Vet Sci. 2021 Mar;135:113

    20. [IF=4.486] Cuijie Li et al."Epidermal growth factor regulation by autophagy‐mediated lncRNA H19 in murine intestinal tract after severe burn."J Cell Mol Med. 2020 May;24(10):5878-5887

    19. [IF=5.192] Chunliu Mi et al."Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells."Chem-Biol Interact. 2022 Jan;351:109729

    18. [IF=5.34] Guanghong Chen et al."Myricetin suppresses the proliferation and migration of vascular smooth muscle cells and inhibits neointimal hyperplasia via suppressing TGFBR1 signaling pathways."Phytomedicine. 2021 Nov;92:153719

    17. [IF=5.546] Cuijie Li et al."Long noncoding RNA H19 act as a competing endogenous RNA of Let‐7g to facilitate IEC‐6 cell migration and proliferation via regulating EGF."J Cell Physiol. 2021 Apr;236(4):2881-2892

    16. [IF=5.959] Pan  Haitao et al."Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation."Cell Death Dis. 2019 Jun;10(6):1-18

    15. [IF=6.529] Xinghui Song et al."Rapamycin alleviates renal damage in mice with systemic lupus erythematosus through improving immune response and function."Biomed Pharmacother. 2021 May;137:111289

    14. [IF=3.476] Duanyang Zhang et al."Autophagy can alleviate severe burn-induced damage to the intestinal tract in mice."Surgery. 2017 Aug;162:408

    13.  Xinghui Song, Jinglin Gao, Huicong Liu, Xiuhua Liu, Kaijiang Tang, Rapamycin alleviates renal damage in mice with systemic lupus erythematosus through improving immune response and function, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111289, ISSN 075

    12.  Li, Cuijie, et al. "Epidermal growth factor regulation by autophagy‐mediated lncRNA H19 in murine intestinal tract after severe burn." Journal of cellular and molecular medicine 24.10 (2020): 5878-5887.https:##doi.org/10.1111/jcmm.15262

    11.  Li, Cuijie, et al. "Long noncoding RNA H19 act as a competing endogenous RNA of Let‐7g to facilitate IEC‐6 cell migration and proliferation via regulating EGF." Journal of cellular physiology 236.4 (2021): 2881-2892.https:##doi.org/10.1002/jcp.30061

    10.  朱鸷翔,沈松鹤,赵森,王大勇,王志学,李荟苹.腹主动脉灌注雷帕霉素联合肝动脉化疗治疗肝移植瘤兔模型疗效分析[J].现代肿瘤医学,2020,28(23):4032-4036.

    9.  蒋鹏娜,王丽洁,李星,李竹英.平喘颗粒对气道上皮细胞自噬及凋亡的抑制作用探讨[J].中国中医急症,2020,29(11):1902-1905.

    8.  饶春梅 成细华 任婷 孙彦波 彭霞 黄政德.加味丹参饮含药血清预处理对缺氧/复氧H9C2心肌细胞自噬相关基因Atg5Beclin1 mRNA表达的影响[J].中国老年学杂志 2017 37(08):1821-1824.

    7.  饶春梅 成细华 任婷 孙彦波 彭霞 黄政德.加味丹参饮含药血清对缺氧/复氧H9C2心肌细胞自噬相关蛋白LC3ⅡBeclin1表达的影响[J].中医杂志 2017 58(12):1043-1048.

    6.  刘波, 陈澍, 杜心灵,. 雷帕霉素降低炎症因子表达水平对小鼠心肌梗死的影响[J]. 华中科技大学学报:医学版, 2013, 42(4):391-391.

    5.  单冬炜,经涛,沈建华,丁冬官,祝兵,谢平,于惠敏.雷帕霉素在视网膜母细胞瘤婴幼儿患者中的应用及对预后的影响[J].肿瘤药学,2017,7(05):605-609.

    4.  蔡旭华,朱伟华,李伟平.西罗莫司对非酒精性脂肪肝大鼠调节性T细胞/辅助性T细胞17平衡的影响[J].中国临床药理学杂志,2017,33(01):36-39.

    3.  郭娟, 张迪, 李龙,. 细胞自噬对犬骨髓间充质干细胞干性的影响[J]. 畜牧兽医学报, 2020, v.51(02):166-174.

    2.  陆树萍, 丁红生. 红景天苷经自噬途径减少脑出血后继发神经损伤的的机制探讨[J]. 中华中医药学刊, 2019(4).

    1.  李竹英,田春燕,蒋鹏娜,马建.基于PI3K/Akt/mTOR信号通路探讨平喘颗粒对气道上皮细胞自噬的作用机制[J].中华中医药杂志,2019,34(11):5094-5098.

    相关实验
    • 吃得少,可以让肌肉更「年轻」?研究证实:热量限制饮食 + 雷帕霉素,有助延缓肌肉衰老

      里限制通过抑制以 mTORC1 为中心的营养感知通路的活动,减轻蛋白质合成负担。mTORC1 抑制剂雷帕霉素(Rapamycin, RM)也在多项研究中被证实可通过调节 mTOR 信号通路从而达到延缓衰老的效果,但这两种方式对肌肉的影响及内在机理仍然是不清晰的。 近日,来自瑞士巴塞尔大学生物中心的研究团队在 Nature Communications 发表了题为 Distinct and additive effects of calorie restriction and rapamycin

    • 「抗衰神药」最新研究来了!生命早期服用雷帕霉素可让雄性小鼠延寿 10%

      导读 雷帕霉素,一款抗衰老的「明星药物」,过去普遍被用于治疗癌症和抗器官移植排斥。然而,最近十年,在从蠕虫到啮齿动物的不同实验动物上都发现,使用雷帕霉素能获得寿命延长的神奇效果,因此雷帕霉素被衰老生物学家们公认为目前最有前途的抗衰老药物候选之一。 2022 年 9 月 16 日,哈佛医学院等单位的研究人员在 Science Advances 发表了题为 Rapamycin treatment during development extends life span and health

    • 三句话读懂一篇 CNS:一次醉酒,也会永久改变大脑;年轻时短期服用雷帕霉素,或可终身抗衰老

      Cohort Study of 94,739 UK Biobank Participants。 该研究纳入了没有心肌梗塞和心衰的 94,739 名英国生物银行参与者,发现每周进行 150~300 分钟中度活动,心衰风险降低 63%,每周进行 75~150 分钟剧烈活动,心衰风险降低 66%,管住嘴迈开腿有助于身体健康! 图 9:来源 Circulation 10. Nature Aging:青壮年短期服用雷帕霉素,或可终身抗衰老 英雄白头,红颜老去,衰老总是带来些许伤感。 2022 年

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