Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, Follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two β A chains, each containing 116 amino acid residues. *Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Catalog #:
120-14
Source :
(BTI-Tn-5B1-4) High-5 Insect Cells*
Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
The ED 50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.