Biotinylated Human CD47 Protein, Avi Tag (Avitag™)
供应商:
ACROBiosystems
规格:
25ug
分子别名: CD47,MER6,IAP,OA3 内毒素: Less than 1.0 EU per μg by the LAL method. 纯度: >95% as determined by SDS-PAGE. 表达区间及表达系统: Biotinylated Human CD47, His Tag (CD7-H82E9) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # NP_942088).Predicted N-terminus: Gln 19
活性:
Immobilized Anti-CD47 MAb, Human IgG4 at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD47, His Tag (Cat. No. CD7-H82E9) with a linear range of 0.07-0.84 ng/mL (QC tested). 背景: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.