相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 规格:
25T
产品编号:TBDCS025107
产品名称:EGFR RTK Activation Dual Detection Kit
产品规格:25T
产品价格:¥询价元
EGFR RTK 活性双重检测试剂盒
EGFR RTK Activation Dual Detection kit includes two directly conjugated antibodies, a phospho-specific Anti-phospho-EGFR (Tyr1173)-Alexa Fluor® 488 and an Anti-EGFR-PerCP conjugated antibody to measure total levels of EGFR. This two color flow cytometry kit is designed to detect the extent of EGF pathway activation by measuring the EGFR phosphorylation in relative to the total EGFR expression in any given cell population. By doing such, the levels of both the total and phosphorylated protein can be measured simultaneously in the same cell, resulting in a normalized and accurate measurement of EGFR activation after stimulation. Moreover, simultaneous measurement of both total and phospho-EGFR confirms target specificity of the phosphorylation event. Together, a total and phospho antibody duo performed in multiplex provides an enhanced and more reliable detection of the phospho:total ratio within a mixed population.
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验绝处逢生,靳令经/李华/叶克强等开发双靶点抑制剂,间接靶向EGFR来治疗胶质母细胞瘤
剂主要有阿法替尼、达克替尼等。第一、二代靶向药疗效显著,但副作用也比较大,且多数患者服用 1-2 年出现耐药性。第一代药物耐药后可用第三代靶向药,主要代表药有奥西替尼等,第三代靶向药亦出现耐药性。然而,现有研究表明使用 EGFR 为靶点治疗胶质瘤仍有许多问题。靶向 EGFR 开发的抗体并未能改善患者的生存率。仅有Panitumumab(帕尼单抗)是唯一可以同时中和 EGFRvIII 和 wtEGFR 的抗体,减弱下游 p-S6 信号,具有良好的体外和体内的抗肿瘤活性。如何发现新的可成药靶点,开发
Receptor Tyrosine Kinase Inhibitor Profiling Using Bead-Based Multiplex Sandwich Immunoassays
Receptor tyrosine kinases (RTK) are important targets in drug discovery processes. Studying the phosphorylation pattern of RTKs enables the determination of their activation and inactivation states. Multiplex bead-based sandwich immunoassays
细菌分离数百个人类SH2- and PTB-位点包含蛋白,研究AR受体以及EGFR、MET和KIT的RTK受体被磷酸化酪氨酸后,与人类基因中含SH2-domain或PTB-domain上百个蛋白之间的相互作用。 随着更多实验的进行,这一方法未来也许能用于临床癌症和其它疾病更精确的诊断,或者用于直接个性化治疗,临床实验受限于大多数的癌症都是通过一种,或者两种标记物进行检测,这种方法容易出错,利用MWA方法,Jones博士表示,“我们就能同时进行多种蛋白检测,而不会仅仅局限于单个的猜想,这是之前从未
技术资料暂无技术资料 索取技术资料





