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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥990.0 |
| 规格： | 50 mg | 产品价格： | ￥3950.0 |
| 规格： | 100 mg | 产品价格： | ￥5706.0 |
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ASP-9521
CAS No. : 1126084-37-4
MCE 国际站：ASP-9521
产品活性：ASP-9521是有效，选择性，有口服活性的AKR1C3抑制剂；对人类AKR1C3的IC50值为11 nM。
研究领域：Others
作用靶点：Others
In Vitro: AKR1C3 is a promising therapeutic target in castrationresistant prostate cancer, as combination of an AKR1C3 inhibitor and a gonadotropin-releasing hormone analogue may lead to complete androgen blockade.ASP-9521 inhibits conversion of androstenedione (AD) into androstenediol and testosterone (T) by recombinant human or cynomolgus monkey AKR1C3 in a concentrationdependent manner (IC50, human: 11 nM; IC50,monkey: 49 nM). ASP-9521 shows more than 100-fold selectivity for AKR1C3 over the isoform AKR1C2. In LNCaP-AKR1C3 cells, ASP-9521 suppresses AD-dependent PSA production and cell proliferation.
In Vivo: In CWR22R xenografts, single oral administration of ASP-9521 (3 mg/kg) inhibits AD-induced intratumoural T production and this inhibitory effect is maintained for 24 h. After oral administration, ASP-9521is rapidly eliminated from plasma, while its intratumoural concentration remained high. The bioavailability of ASP-9521 after oral administration (1 mg/kg) is 35 %, 78 % and 58 % in rats, dogs and monkeys, respectively.
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文献和实验solution = hypoxantine, 340 mg ddH2O up to 50 ml NaOH 1 N, 3 ml - heat to 37℃6、thymidine solution = thymidine (2'-desoxy-thymidine), 96 mg ddH2O up to 50 ml7、AJ (from "ajouter" , to add, local slang), 3 L, 0.22 (or 0.45) µm-filtered, store at -20℃= Asp-Arg
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Fusion is an important procedure to produce monoclonal antibodies (MoAb).
up to 50 ml + NaOH 1 N, 3 ml -> heat to 37ѓC thymidine solution = thymidine (2'-desoxy-thymidine), 96 mg + ddH2 O up to 50 ml AJ (from "ajouter" , to add, local slang), 3 L, 0.22 (or 0.45) µm-filtered, store at -20ѓC = Asp-Arg x100
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