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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
| 规格： | 100 mg | 产品价格： | ￥8500.0 |
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AA26-9
CAS No. : 1312782-34-5
MCE 国际站：AA26-9
产品活性：AA26-9 是一种高效的广谱丝氨酸水解酶 (serine hydrolase) 抑制剂。AA26-9 靶点包括丝氨酸肽酶、脂肪酶、酰胺酶、酯酶和硫酯酶。AA26-9 对永生化 T 细胞系中检测到的 40+ 丝氨酸水解酶中的 1/3 有抑制作用。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phospholipase
In Vitro: AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.
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文献和实验AA Metabolite Quantitation of Media Post-AA Labeling
TLC plate for TLC system #1, use 20µl to spot a linear K TLC plate for TLC system #2. TLC : A) Allow TLC tanks to equilibrate 1-2 hrs with solvent prior to running. SYSTEM #1 --> SeparatesPA, TXB2, HHT, HETE & AA. ethylacetate
AA Metabolite Quantitation of Cell Pellets Post-AA Labeling
. SYSTEM #1 --> SeparatesPA, TXB2, HHT, HETE & AA. ethylacetate/2,2,4-trimethylpentane/acetic acid/ H2O at a ratio of 90:50:20:100 SYSTEM #2 --> Separates DAG & AA. benzene/diethyl ether/ethanol/NH3 at a ratio of 100:80:4:0.2 B) Following TLC remove plates
AA & Metabolite Quantitation of Media Post-AA
AA & Metabolite Quantitation of Media Post-AA Labeling Contributor: Suprya Jayadev Date: November 4, 1994 1) Remove 2 500 µl aliquots of supernatant into scintillation vials, add scintillation fluid and count
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