- ￥391 - 5713
- MedChemExpress(MCE)
- 美国
- HY-15272
- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1062159-35-6
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥391.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1185.0 |
| 规格： | 10 mg | 产品价格： | ￥1613.0 |
| 规格： | 25 mg | 产品价格： | ￥2825.0 |
| 规格： | 50 mg | 产品价格： | ￥4063.0 |
| 规格： | 100 mg | 产品价格： | ￥5713.0 |
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WAY-600
CAS No. : 1062159-35-6
MCE 国际站：WAY-600
产品活性：WAY-600 是有效，ATP 竞争型，选择性的 mTOR 抑制剂，抑制重组 mTOR 酶的 IC50 值为 9 nM。WAY-600 阻断 mTOR 复合物 1/2 (mTORC1/2) 组装和激活。
研究领域：PI3K/Akt/mTOR
作用靶点：mTOR
In Vitro: WAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).
In Vivo: Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily).
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